Systemic Autoimmune Diseases

Abnormal presence of autoantibodies such as anti-nuclear antibodies (ANA) and extractable nuclear antibodies (ENA) are consider as major autoimmune markers.  ANA are shown by immunofluorescence patterns.  Common systemic autoimmune diseases are:

Systemic Lupus Erythematosus (SLE)

Mixed Connective Tissue Diseases (MCTD)

Systemic Sclerosis

Sjögren’s Syndrome

The following autoimmune antibodies are useful for the detection of SLE: dsDNA, Histones, Nucleosome, SSA (Ro), SSB (La), Sm, RNP, Ribosome P, PCNA, Jo-1, Scl70, PMScl and Centromere.

Use our complete range of Immunofluorescence (IFA) products from Immco, Zeus Scientific and AlphaDia for cell or tissue based slides for the detection of major autoantibodies.

Characterise autoantibodies with our range of ELISA assays or DotBlot assays that are calibrated to latest international standards and provide qualitative or quantitative results.

Anti-Phospholipid Syndrome

The presence of antiphospholipid (aPL) antibodies and its cofactor β2-glycoprotein I help to identify patients at risk for antiphospholipid syndrome (APS). APS may involve venous and/or arterial thrombosis, thrombocytopenia and recurrent foetal loss.

AUTOZYMETM ACL, anti-cardiolipin IgA, IgG and IgM Elisa assays provide excellent quantification, ideal for routine use on Elisa processors such as the Dynex DS2.

Product Codes:

Z4496: AUTOZYMETM ACL IgA - download the datasheet

Z4596: AUTOZYMETM ACL IgG - download the datasheet

Z4696: AUTOZYMETM ACL IgM - download the datasheet

These assays are complemented with assays for anti-β2-glycoprotein 1, phosphatidyserine, oxLDL antibodies and annexin-V.

Rheumatoid Arthritis

Rheumatoid Arthritis (RA) is a chronic, progressive systemic autoimmune disease characterised by persistent joint inflammation.  If left untreated,  the disease leads to systemic complications, irresversible joint damage and invalidity. Serological markers can detect early stage RA to lead to improved outcome of RA therapy and reduction of severity of joint damage.

Serolgical markers include Rheumatoid Factor (RF) and antibodies against cyclic citrullinated peptides (Anti-CCP).

AUTOZYMETM RF IgA, IgG and IgM Elisa assays provide excellent quantification, ideal for routine use on Elisa processors such as the Dynex DS2.

Product Codes:

Z9196: AUTOZYMETM RF IgA - download the datasheet

Z9296: AUTOZYMETM RF IgG - download the datasheet

Z9396: AUTOZYMETM RF IgM - download the datasheet

CLS also can provide RF and anti-CCP elisa assays and assays that are suitable for clinical chemistry analysers.

Resources

CodeDescriptionMSDSInstructions for use
Z4496AUTOZYME™ ACL IgA
Z4596AUTOZYME™ ACL IgG
Z4696AUTOZYME™ ACL IgM
Z9196AUTOZYME™ RF IgA
Z9296AUTOZYME™ RF IgM
Z9396AUTOZYME™ RF IgG
Immco ELISA Products IFU + MSDSProducts from Trinity Biotech
ZEUS ELISA™ Products IFU + MSDSProducts from Zeus Scientific
Zeus IFA™ Products IFU + MSDSProducts from Zeus Scientific
ImmuGlo™ IFA Products IFU + MSDSProducts from Trinity Biotech
IFA Products IFU + MSDSProducts from AlphaDia
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