Systemic Autoimmune Diseases

Abnormal presence of autoantibodies such as anti-nuclear antibodies (ANA) and extractable nuclear antibodies (ENA) are consider as major autoimmune markers.  ANA are shown by immunofluorescence patterns.  Common systemic autoimmune diseases are:

Systemic Lupus Erythematosus (SLE)

Mixed Connective Tissue Diseases (MCTD)

Systemic Sclerosis

Sjögren’s Syndrome

The following autoimmune antibodies are useful for the detection of SLE: dsDNA, Histones, Nucleosome, SSA (Ro), SSB (La), Sm, RNP, Ribosome P, PCNA, Jo-1, Scl70, PMScl and Centromere.

Use our complete range of Immunofluorescence (IFA) products from Immco, Zeus Scientific and AlphaDia for cell or tissue based slides for the detection of major autoantibodies.

Characterise autoantibodies with our range of ELISA assays or DotBlot assays that are calibrated to latest international standards and provide qualitative or quantitative results.

Anti-Phospholipid Syndrome

The presence of antiphospholipid (aPL) antibodies and its cofactor β2-glycoprotein I help to identify patients at risk for antiphospholipid syndrome (APS). APS may involve venous and/or arterial thrombosis, thrombocytopenia and recurrent foetal loss.

AUTOZYME^TM ACL, anti-cardiolipin IgA, IgG and IgM Elisa assays provide excellent quantification, ideal for routine use on Elisa processors such as the Dynex DS2.

Product Codes:

Z4496: AUTOZYME^TM ACL IgA

Z4596: AUTOZYME^TM ACL IgG

Z4696: AUTOZYME^TM ACL IgM

Download the datasheet

These assays are complemented with assays for anti-β2-glycoprotein 1, phosphatidyserine, oxLDL antibodies and annexin-V.

Rheumatoid Arthritis

Rheumatoid Arthritis (RA) is a chronic, progressive systemic autoimmune disease characterised by persistent joint inflammation.  If left untreated,  the disease leads to systemic complications, irresversible joint damage and invalidity. Serological markers can detect early stage RA to lead to improved outcome of RA therapy and reduction of severity of joint damage.

Serolgical markers include Rheumatoid Factor (RF) and antibodies against cyclic citrullinated peptides (Anti-CCP).

AUTOZYME^TM RF IgA, IgG and IgM Elisa assays provide excellent quantification, ideal for routine use on Elisa processors such as the Dynex DS2.

Product Codes:

Z9196: AUTOZYME^TM RF IgA

Z9296: AUTOZYME^TM RF IgG

Z9396: AUTOZYME^TM RF IgM

Download the AUTOZYME^TM RF datasheet.

CLS also can provide RF and anti-CCP elisa assays and assays that are suitable for clinical chemistry analysers.

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