Inflammatory myopathies are uncommon diseases affecting primarily muscle tissue and / or the skin. Diagnosis is difficult since overlap syndromes with features of other diseases such as Scleroderma are frequent.
Polymyositis / Dermatomyositis
Certain autoantibodies have been considered 'myositis specific' because most patients with them have myositis. The most common autoantibodies are the anti-synthetases directed against aminoacyl tRNA synthetases. These include Jo-1, PL7, PL12, other autoantibodies that are useful include SRP, Mi-2, Ku, Anti-PMScl is often considered a myositis autoantibody since 80% of patients have myositis.
These autoantibodies tend to produce cytoplasmic patterns HEp2 cells by IFA, except anti-Mi-2 which are nuclear speckled and anti-PMScl which are nucleolar. BlueDiver Dot kits allow the characterisation of the autoantibodies relating to PM/DM. Kits and the BlueDiver Instrument are available through CLS.
|Code||Description||MSDS||Instructions for use|
|FA2400||ANA HEp-2 Test System|
|MYOS12DIV-24||BlueDiver Dot Myositis 12 Parameters|
|PMS12DIV-24||BlueDiver Dot Polymyositis/Scleroderma 12 IgG|