Neurological Autoimmune Diseases

Paraneoplastic Neurological Syndromes

Paraneoplastic neurological disorders are rare debilitating neurological illnesses associated with remote effects of a malignant neoplasm (e.g., small cell lung cancer, breast and gynaecological tumours).  Very often the symptoms precede the detection of the paraneoplastic tumours. 

CLS offers a comprehensive panel of neurology tests to aid in diagnosis of various autoimmune mediated neuropathies and paraneoplastic with confirmation for the most common markers. IFA on cerebellar tissue is the initial screen for anti-neuronal antibodies and Blot assys are used to confirm the specificities.  Paraneoplastic neurological antibodies that target neuronal nuclei of the central nervous system are anti-Hu (ANNA-1), anti-Ri (ANNA-2), ANNA-3 and anti-Ma.  Paraneoplastic neurological antibodies that target antigens in the cytoplasm of the Purkinje cell are anti-Yo (PCA1), PCA2 and anti-Tr (PCA-Tr).  Other paraneoplastic neurological antibodies are anti-amphiphysin, anti-CV2/CRMP5, anti-GAD65 and anti-Zic4, all of which are measured using the PNS11 Diver assay. 

Myelin Associated Antibodies (MAG)

Antibodies to myelin proteins are associated with demyelinative diseases such as multiple sclerosis and peripheral neuropathy.  Detection is usually performed by Western Blot or LineBlot assays which are available through CLS.

Ganglioside Antibodies

Inflammatory neuropathies of the peripheral nervous system are characterized by numerous clinical symptoms ranging from slight weariness and uncharacteristic indisposition to neuromuscular disorders and functional deficiency like respiratory paralysis and cardiac arrest. Autoantibodies to gangliosides have been identified in patients suffering from disorders of the peripheral nervous system. Anti-gangliosides autoantibodies IgM are associated to chronic neuropathies and the IgG subtype are observed in acute neuropathies.  IgG or IgM autoantibodies can be measured on BlueDiver Combi kits.

Myasthenia Gravis (MG)

Myasthenia Gravis (MG) is a disorder in which autoantibodies to acetylcholine receptors (AChR) at the neurmuscular junction of the skeletal muscle lead to AChR loss and muscle weakness.

The ElisaRSR™ AChR Ab Acetylcholine Receptor (AChR) Autoantibody Elisa Kit is for the quantitative determination of autoantibodies to acetylcholine receptor in serum. Suitable for both foetal and adult AChR in MG.

Product Codes:

ACE/96: ElisaRSR™ AChR Ab - download the datasheet.

 

 

 

 

Resources

CodeDescriptionMSDSInstructions for use
ACE/96ElisaRSR™ AChR Ab Elisa Kit
PNS11 DiverPNS11 Diver Blot IgG
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