Type 1 Diabetes

Type I Diabetes Mellitus - Insulin Dependent Diabetes Mellitus (IDDM)

Diabetes mellitus (DM) is a metabolic disorder characterised by chronic hyperglycemia, with disturbances of carbohydrate, fat, and protein metabolism resulting from defects in insulin secretion, action or both. Type 1A DM is the major requiring exogenous insulin for survival and preventing ketosis as a consequence of β-cell destruction and also the principal autoimmune DM form because of a cellular-mediated, organ specific, progressive β-cell destruction.  Autoimmune isdescribed by the presence of more than one of the specific autoantibodies; anti-GAD65, anti-insulin, anti-IA-2.

CLS offer the ELISA assays from RSR Ltd:

ElisaRSR™ GADAb - Glutamic Acid Decarboxylase (GAD) Autoantibody Elisa Kit; Product Code - GDE/96

ElisaRSR™ IA-2 Ab v2 - IA-2 Autoantibody (version 2) Elisa Kit; Product Code - IAE/96/2

ElisaRSR™ 2 Screen ICA™ - 2 Screen Islet Cell Autoantibody Elisa Kit; Product Code - 2GI/96

ElisaRSR™ ZnT8 Ab™ - Zinc Transporter 8 (ZnT8) Autoantibody Elisa Kit; Product Code - ZnT8/96

 

Autoantibodies for Type 1 DM can also be detected using immunofluorescence on primate pancreas tissue slides.

 

 

 

Resources

CodeDescriptionMSDSInstructions for use
GDE/96ElisaRSR™ GAD Ab Elisa Kit
IAE/96/2ElisaRSR™ IA-2 Ab Elisa Kit
2GI/96ElisaRSR™ 2 Screen ICA™ Ab Elisa Kit
ZnT8/96ElisaRSR™ Zinc Transporter Autoantibody Elisa Kit
1123ImmuGlo™ Islet Cell Antibody
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